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publications

Below we have listed a collection of the latest publications of members of the Lipid Research Center.

Exclusive photorelease of signalling lipids at the plasma membrane

Nadler, A., Yushchenko, D. A., Muller, R., Stein, F., Feng, S., Mulle, C., Carta, M., and Schultz, C. (2015) Nat Commun 6, 10056 doi:10.1038/ncomms10056

Regulation of Liver Metabolism by the Endosomal GTPase Rab5

Zeigerer, A., Bogorad, R. L., Sharma, K., Gilleron, J., Seifert, S., Sales, S., Berndt, N., Bulik, S., Marsico, G., D’Souza, R. C. J., Lakshmanaperumal, N., Meganathan, K., Natarajan, K., Sachinidis, A., Dahl, A., Holzhütter, H.-G., Shevchenko, A., Mann, M., Koteliansky, V., and Zerial, M. (2015) Cell Reports. 11, 884–892

RDGBalpha, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction

Yadav, S., Garner, K., Georgiev, P., Li, M., Gomez-Espinosa, E., Panda, A., Mathre, S., Okkenhaug, H., Cockcroft, S., and Raghu, P. (2015) J Cell Sci 128, 3330-3344

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

Villaseñor, R., Nonaka, H., Del Conte-Zerial, P., Kalaidzidis, Y., and Zerial, M. (2015) eLife. 4, 7875

STED-FLCS: An Advanced Tool to Reveal Spatiotemporal Heterogeneity of Molecular Membrane Dynamics

Vicidomini, G., Ta, H., Honigmann, A., Mueller, V., Clausen, M. P., Waithe, D., Galiani, S., Sezgin, E., Diaspro, A., Hell, S. W., and Eggeling, C. (2015) Nano Lett. 15, 5912–5918

An automated shotgun lipidomics platform for high throughput, comprehensive, and quantitative analysis of blood plasma intact lipids

Surma, M. A., Herzog, R., Vasilj, A., Klose, C., Christinat, N., Morin-Rivron, D., Simons, K., Masoodi, M., and Sampaio, J. L. (2015) Eur. J. Lipid Sci. Technol. 117, 1540–1549

Adaptive Lipid Packing and Bioactivity in Membrane Domains

Sezgin, E., Gutmann, T., Buhl, T., Dirkx, R., Grzybek, M., Coskun, Ü., Solimena, M., Simons, K., Levental, I., and Schwille, P. (2015) PLoS ONE. 10, e0123930

Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin

Saha, S., Lee, I. H., Polley, A., Groves, J. T., Rao, M., and Mayor, S. (2015) Mol Biol Cell 26, 4033-4045

GPI-anchored protein organization and dynamics at the cell surface

Saha, S., Anilkumar, A. A., and Mayor, S. (2015) J Lipid Res

Hopanoids as functional analogues of cholesterol in bacterial membranes

Sáenz, J. P., Grosser, D., Bradley, A. S., Lagny, T. J., Lavrynenko, O., Broda, M., and Simons, K. (2015) Proc Natl Acad Sci USA. 112, 11971–11976

Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins

Raghupathy, R., Anilkumar, A. A., Polley, A., Singh, P. P., Yadav, M., Johnson, C., Suryawanshi, S., Saikam, V., Sawant, S. D., Panda, A., Guo, Z., Vishwakarma, R. A., Rao, M., and Mayor, S. (2015) Cell 161, 581-594

Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans

Penkov, S., Kaptan, D., Erkut, C., Sarov, M., Mende, F., and Kurzchalia, T. V. (2015) Nat Comms. 6, 8060

The LUX Score: A Metric for Lipidome Homology

Marella, C., Torda, A. E., and Schwudke, D. (2015) PLoS Comput Biol 11, e1004511

Co-option of Membrane Wounding Enables Virus Penetration into Cells

Luisoni, S., Suomalainen, M., Boucke, K., Tanner, L. B., Wenk, M. R., Guan, X. L., Grzybek, M., Coskun, Ü., and Greber, U. F. (2015) Cell Host & Microbe. 18, 75–85

Structural Basis of Dynamic Membrane Recognition by trans-Golgi Network Specific FAPP Proteins

enoir, M., Grzybek, M., Majkowski, M., Rajesh, S., Kaur, J., Whittaker, S. B. M., Coskun, Ü., and Overduin, M. (2015) J Mol Biol 427, 966-981

Live cell plasma membranes do not exhibit a miscibility phase transition over a wide range of temperatures.

Lee, I. H., Saha, S., Polley, A., Huang, H., Mayor, S., Rao, M., and Groves, J. T. (2015) J Phys Chem B 119, 4450-4459

The ecdysteroidome of Drosophila: influence of diet and development

Lavrynenko, O., Rodenfels, J., Carvalho, M., Dye, N. A., Lafont, R., Eaton, S., and Shevchenko, A. (2015) Development. 142, 3758–3768

N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes

Kaszuba, K., Grzybek, M., Orłowski, A., Danne, R., Róg, T., Simons, K., Coskun, Ü., and Vattulainen, I. (2015) Proc Natl Acad Sci USA. 112, 4334–4339

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.

Kalaidzidis, I., Miaczynska, M., Brewinska-Olchowik, M., Hupalowska, A., Ferguson, C., Parton, R. G., Kalaidzidis, Y., and Zerial, M. (2015) The Journal of Cell Biology. 211, 123–144

Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants

Hebbar, S., Sahoo, I., Matysik, A., Argudo Garcia, I., Osborne, K. A., Papan, C., Torta, F., Narayanaswamy, P., Fun, X. H., Wenk, M. R., Shevchenko, A., Schwudke, D., and Kraut, R. (2015) Sci Rep 5, 15926

The C. elegans dauer larva as a paradigm to study metabolic suppression and desiccation tolerance

Erkut, C., and Kurzchalia, T. V. (2015) Planta. 242, 389–396

A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors

Chakrabarti, P., Kolay, S., Yadav, S., Kumari, K., Nair, A., Trivedi, D., and Raghu, P. (2015) PLoS Genet 11, e1004948

Quantitative profiling of endocannabinoids in lipoproteins by LC–MS/MS

Bilgin, M., Bindila, L., Graessler, J., and Shevchenko, A. (2015) Anal Bioanal Chem. 407, 5125–5131

Two-Dimensional Trap for Ultrasensitive Quantification of Transient Protein Interactions

Beutel, O., Roder, F., Birkholz, O., Rickert, C., Steinhoff, H.-J., Grzybek, M., Coskun, Ü., and Piehler, J. (2015) ACS Nano. 9, 9783–9791

Phosphoinositide signalling in Drosophila

Balakrishnan, S. S., Basu, U., and Raghu, P. (2015) Biochim Biophys Acta 1851, 770-784

Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors

Yadav, M., Raghupathy, R., Saikam, V., Dara, S., Singh, P. P., Sawant, S. D., Mayor, S., and Vishwakarma, R. A. (2014) Org Biomol Chem 12, 1163-1172

Products of the Parkinson’s disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

Toyoda, Y., Erkut, C., Pan-Montojo, F., Boland, S., Stewart, M. P., Muller, D. J., Wurst, W., Hyman, A. A., and Kurzchalia, T. V. (2014) Biology Open. 3, 777–784

Deducing the mechanism of action of compounds identified in phenotypic screens by integrating their multiparametric profiles with a reference genetic screen

Sundaramurthy, V., Barsacchi, R., Chernykh, M., Stöter, M., Tomschke, N., Bickle, M., Kalaidzidis, Y., and Zerial, M. (2014) Nat Protoc. 9, 474–490

Measuring Lipid Packing of Model and Cellular Membranes with Environment Sensitive Probes

Sezgin, E., Sadowski, T., and Simons, K.
(2014) Langmuir. 30, 8160–8166

Unique, polyfucosylated glycan-receptor interactions are essential for regeneration of Hydra magnipapillata

Sahadevan, S., Antonopoulos, A., Haslam, S. M., Dell, A., Ramaswamy, S., and Babu, P. (2014) ACS Chem Biol 9, 147-155

Bilayer registry in a multicomponent asymmetric membrane: dependence on lipid composition and chain length

Polley, A., Mayor, S., and Rao, M. (2014) J Chem Phys 141, 064903

Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations

Perini, E. D., Schaefer, R., Stöter, M., Kalaidzidis, Y., and Zerial, M. (2014) Traffic. 15, 1366–1389

A wax ester promotes collective host finding in the nematode Pristionchus pacificus

Penkov, S., Ogawa, A., Schmidt, U., Tate, D., Zagoriy, V., Boland, S., Gruner, M., Vorkel, D., Verbavatz, J.-M., Sommer, R. J., Knölker, H.-J., and Kurzchalia, T. V. (2014) Nat Chem Biol. 10, 281–285

Systematic Screening for Novel Lipids by Shotgun Lipidomics

Papan, C., Penkov, S., Herzog, R., Thiele, C., Kurzchalia, T., and
Shevchenko, A. (2014) Anal. Chem. 86, 2703–2710

Apical Localisation of Crumbs in the Boundary Cells of the Drosophila Hindgut Is Independent of Its Canonical Interaction Partner Stardust

Kumichel, A., and Knust, E. (2014) PLoS ONE. 9, e94038

Host Cell Phosphatidylcholine Is a Key Mediator of Malaria Parasite Survival during Liver Stage Infection

Itoe, M. A., Sampaio, J. L., Cabal, G. G., Real, E., Zuzarte-Luis, V., March, S., Bhatia, S. N., Frischknecht, F., Thiele, C., Shevchenko, A., and Mota, M. M. (2014)Cell Host & Microbe. 16, 778–786

Laser capture microdissection coupled with on-column extraction LC-MS(n) enables lipidomics of fluorescently labeled Drosophila neurons

Hebbar, S., Schulz, W. D., Sauer, U., and Schwudke, D. (2014) Anal Chem 86, 5345-5352

Chaoptin, prominin, eyes shut and crumbs form a genetic network controlling the apical compartment of Drosophila photoreceptor cells

Gurudev, N., Yuan, M., and Knust, E. (2014) PLoS ONE. 9, e94038

How worms survive desiccation

Erkut, C., Penkov, S., Fahmy, K., and Kurzchalia, T. V. (2014) Worm. 1, 61–65

Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia

Subramanian, M., Metya, S. K., Sadaf, S., Kumar, S., Schwudke, D., and Hasan, G. (2013) Dis Model Mech 6, 734-744

Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development

A., Toscano, S., Trivedi, D., Jones, D. R., Mathre, S., Clarke, J. H., Divecha, N., and Raghu, P. (2013) Proc Natl Acad Sci U S A 110, 5963-5968

Lipid signaling in Drosophila photoreceptors

Raghu, P., Yadav, S., and Mallampati,  N. B. (2012) Biochim Biophys Acta 1821, 1154-1165

Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development

Rodenfels, J., Lavrynenko, O., Ayciriex, S., Sampaio, J. L., Carvalho, M., Shevchenko, A., and Eaton, S. (2014) Genes Dev. 28, 2636–2651

The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans

Abusharkh, S. E., Erkut, C., Oertel, J., Kurzchalia, T. V., and Fahmy, K. (2014) Langmuir. 30, 12897–12906

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

Bogorad, R. L., Yin, H., Zeigerer, A., Nonaka, H., Ruda, V. M., Zerial, M., Anderson, D. G., and Koteliansky, V. (2014) Nat Comms. 10.1038/ncomms4869

Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation

Erkut, C., Vasilj, A., Boland, S., Habermann, B., Shevchenko, A., and Kurzchalia, T. V.(2013) PLoS ONE. 8, e82473

Plasma Lipid Composition and Risk of Developing Cardiovascular Disease

Fernandez, C., Sandin, M., Sampaio, J. L., Almgren, P., Narkiewicz, K., Hoffmann, M., Hedner, T., Wahlstrand, B., Simons, K., Shevchenko, A., James, P., and Melander, O. (2013) PLoS ONE. 8, e71846

A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress

Surma, M. A., Klose, C., Peng, D., Shales, M., Mrejen, C., Stefanko, A., Braberg, H., Gordon, D. E., Vorkel, D., Ejsing, C. S., Farese, R., Jr., Simons, K., Krogan, N. J., and Ernst, R. (2013) Molecular Cell. 51, 519–530

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Gilleron, J., Querbes, W., Zeigerer, A., Borodovsky, A., Marsico, G., Schubert, U., Manygoats, K., Seifert, S., Andree, C., Stöter, M., Epstein-Barash, H., Zhang, L., Koteliansky, V., Fitzgerald, K., Fava, E., Bickle, M., Kalaidzidis, Y., Akinc, A., Maier, M., and Zerial, M. (2013) Nat Biotechnol. 31, 638–646

Crumbs Affects Protein Dynamics In Anterior Regions Of The Developing Drosophila Embryo

Firmino, J., Tinevez, J.-Y., and Knust, E. (2013) PLoS ONE. 8, e58839

Photoconversion of Bodipy-Labeled Lipid Analogues

Sezgin, E., Chwastek, G., Aydogan, G., Levental, I., Simons, K., and Schwille, P. (2013) ChemBioChem. 14, 695–698

Fosmid-Based Structure-Function Analysis Reveals Functionally Distinct Domains in the Cytoplasmic Domain of Drosophila Crumbs

Klose, S., Flores-Benitez, D., Riedel, F., and Knust, E. (2013) G3 3, 153–165

Integration of Chemical and RNAi Multiparametric Profiles Identifies Triggers of Intracellular Mycobacterial Killing

Sundaramurthy, V., Barsacchi, R., Samusik, N., Marsico, G., Gilleron, J., Kalaidzidis, I., Meyenhofer, F., Bickle, M., Kalaidzidis, Y., and Zerial, M. (2013) Cell Host & Microbe. 13, 129–142

Active remodeling of cortical actin regulates spatiotemporal organization of cell surface molecules.

Gowrishankar, K., Ghosh, S., Saha, S., C, R., Mayor, S., and Rao, M. (2012) Cell 149, 1353-1367

Identification of a suppressor of retinal degeneration in Drosophila photoreceptors.

Georgiev, P., Toscano, S., Nair, A., Hardie, R., and Raghu, P. (2012) J Neurogenet 26, 338-347

Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid.

Garner, K., Hunt, A. N., Koster, G., Somerharju, P., Groves, E., Li, M., Raghu, P., Holic, R., and Cockcroft, S. (2012) J Biol Chem 287, 32263-32276

SnapShot: Mammalian Rab Proteins in Endocytic Trafficking

Galvez, T., Gilleron, J., Zerial, M., and O’Sullivan, G. A. (2012) Cell. 151, 234–234.e2