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Imaging the future

Research in LRC focuses on the intricate interplay between lipids themselves and with the proteins in the bilayer to capture these interactions both in the living cell and in reconstituted model systems.

This will be facilitated by the new imaging methods that can observe cellular processes with high spatio-temporal resolution and deliver quantitative readouts.

Attempts have been initiated to place the lipids in the context of developmental processes and come to grips with how lipids contribute to cell polarity and homeostasis.

It will also be important to develop new lipid probes and tools to study lipid function both in and ex vivo. Understanding cellular processes will demand the development of sophisticated reconstitution methods to reduce the cellular machineries to their core components and unravel how they function.

MPI-CBG and NCBS complement each other in this respect. Both sites also have superb computational experts to predictably model the processes under study. A concerted effort is underway to employ the cutting edge shotgun mass spectrometric platform to unravel lipidomic blood  signatures to understand why Indians are so prone to diabetes type 2, a scourge formankind worldwide.

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modules

There are 3 main modules and 9 fields. Click the bars to open and learn more.

  • Basic Research

    Structure of membrane
    What is the role of actin cytoskeleton, different bilayer lipids and proteins in regulating membrane sub-compartmentalization?

    Signaling
    How do bilayer and signaling lipids contribute to signal transduction processes across cell membranes?

    Proteomics, Lipidomics
    How do lipids regulate specific membrane proteins?

    Cell Polarity, homeostasis
    Apical and basolateral plasma membrane domains have different lipid and protein compositions. How do these biomolecules contribute to cell polarization and maintenance?

    Lipid metabolism
    Lipids are emerging as major players in cell metabolism and nutritition. How do they perform these functions?

  • Technology & Resources

    Proteomics, Lipidomics
    Which methods can we use to study protein-lipid interactions and metabolic pathways?

    Technologies
    How can we synthesize lipid probes that can be followed in cells and tissues and mimic the properties of their native counterparts?

    Lipid databases
    The LRC will support ongoing efforts to come up with functional and effective databases for lipids by organizing international workshops where open issues and future developments are discussed.

  • Biomedical Research

    Diabetes
    LRC will organize screening of blood samples from Indian children and adults to identify multiparametric lipidomic signatures to find out how they differ from other ethnic groups

    Liver Steatosis

    Retinis Pigmaentosa