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Satyajit Mayor

NCBS | Professor

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  • Basic Research

    Structure of membrane
    Lipidomics

  • Technology and Resources

    Lipidomics

Project Description

Mayor laboratory collaborates with :

Andre Nadler: On the synthesis of lipid probes to study membrane organization
Here we will:

  1. Synthesize PS based probes that can be photoactivated to modulate the levels of PS at the plasma membrane. This would provide an efficient system to tune membrane (inner leaflet) composition and see its effect on membrane order and investigate any consequent homeostasis mechanisms in place.
  2. Synthesize probes where PS is tagged to a solvatochromic backbone in order to measure liquid order parameter from the inner leaflet of the plasma membrane
  3. While synthesis of the probes will be in Dresden, studies on membrane organization in different contexts will be carried out in Bangalore.


Suzanne Eaton: To study membrane organizational homeostasis

Study of membrane order homeostasis in-vivo using drosophila wing disc as a model system. Flies grown on different lipid diets and maintained at different temperatures (as expected to be the case in the wild with change in seasons) are expected to show homeostasis in their membrane parameters such as membrane order in viable temperature range.This would be important to operate all signalling networks with optimal efficiency at the plasma membrane. This is the idea we intend to test with this model system.

Marino Zerial
To explore the role of the CLIC/GEEC endocytic pathway in regulating hepatic bile duct tension homeostasis.
Here we will explore the contributions of the diverse endocytic pathways in the construction and maintenance of the special architecture of hepatic tissue with special emphasis on the role of the CG endocytic pathway in this process.

  • Collection of Lipid Center relevant Publications

    2018
    Thottacherry JJ, Kosmalska AJ, Kumar A, Vishen AS, Elosegui-Artola A, Pradhan S, Sharma S, Singh PP, Guadamillas MC, Chaudhary N, Vishwakarma R, Trepat X, Del Pozo MA, Parton RG, Rao M, Pullarkat P, Roca-Cusachs P, Mayor S. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nat Commun. 2018 Oct 11;9(1):4217

    Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S. Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis. Nat Commun. 2018 May 9;9(1):

    Jha A, van Zanten TS, Philippe JM, Mayor S, Lecuit T. Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis. Curr Biol. 2018 May 21;28(10):1570-1584.e6

    Parchure A, Vyas N, Mayor S. Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens. Trends Cell Biol. 2018 Feb;28(2):157-170

    Freeman SA, Vega A, Riedl M, Collins RF, Ostrowski PP, Woods EC, Bertozzi CR, Tammi MI, Lidke DS, Johnson P, Mayor S, Jaqaman K, Grinstein S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018 Jan 11;172(1-2):305-317.e10

    2017
    Nordenfelt P, Moore TI, Mehta SB, Kalappurakkal JM, Swaminathan V, Koga N, Lambert TJ, Baker D, Waters JC, Oldenbourg R, Tani T, Mayor S, Waterman CM, Springer TA. Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. Nat Commun. 2017 Dec 11;8(1):2047

    Swaminathan V, Kalappurakkal JM, Mehta SB, Nordenfelt P, Moore TI, Koga N, Baker DA, Oldenbourg R, Tani T, Mayor S, Springer TA, Waterman CM. Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10648-10653

    Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23;169(1):108-119.e20

    Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane organization: composition, regulation and roles of lipid rafts. Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374