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Varadha Sundaramurthy

NCBS | Group Leader

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  • Basic Research

    Lipidomics

  • Technology & Resources

    Lipidomics

Project Description

My lab in NCBS works on host-pathogen interactions. We are interested in understanding how fundamental processes in the host cell such as trafficking are modulated by intracellular pathogens. An ongoing active project in the lab aims to understand the alterations in macrophage endo-lysosomal pathway during M. tuberculosis infections. We have recently identified several Mtb lipids that modulate host cell trafficking. While these studies have been done with purified Mtb lipids, the challenge is to understand the relevance of these modulations during pathogenesis. Hence, it becomes imperative to develop methods to identify and possibly quantify individual lipids in situ. This is particularly challenging, since Mtb has several unique lipid species that are not found elsewhere. With this long term aim, we work with the Nadler and Shevchenko groups in MPI-CBG to develop lipid probes that can label Mtb lipids, which can further used for their detection. Successful development of these methods will allow careful quantitation of individual lipid species between different clinical strains of Mtb, or infection contexts, and establish correlates with diverse aspects of pathogenesis mechanisms.

  • Collection of Lipid Center relevant Publications

    2017
    Sundaramurthy V, Korf H, Singla A, Scherr N, Nguyen L, Ferrari G, Landmann R, Huygen K, Pieters J. Survival of Mycobacterium tuberculosis and Mycobacterium bovis BCG in lysosomes in vivo. Microbes Infect. 2017 Nov;19(11):515-526